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1. (WO2018039648) SYSTEM AND METHODS FOR PROCESSING NEURAL SIGNALS

Pub. No.:    WO/2018/039648    International Application No.:    PCT/US2017/048759
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Sat Aug 26 01:59:59 CEST 2017
IPC: A61N 1/05
A61N 1/04
A61N 1/02
A61B 5/04
Applicants: PARADROMICS, INC.
Inventors: ANGLE, Matthew
HUBER, Edmund
EDGINGTON, Robert
Title: SYSTEM AND METHODS FOR PROCESSING NEURAL SIGNALS
Abstract:
Systems and methods for processing neural signals are provided. A neural data analysis system may comprise a feature extraction module configured to (1) extract a plurality of features from neural signal waveforms obtained by an implanted neural interface probe with a plurality of channels or electrodes, wherein the plurality of features are extracted from the neural signal waveforms without requiring prior digitization of the neural signal waveforms, and (2) to transmit the extracted features as a plurality of discrete outputs. The neural data analysis system may also comprise a feature-event coalescence module configured to: (1) receive the plurality of discrete outputs from the feature extraction module, and (2) construct a model-based inference of bioelectric activity based on feature-event statistics, prior knowledge of bioelectric signals, and/or a behavioral model of the feature-extraction module. The neural data analysis system may further comprise an approximator module configured to (1) receive a plurality of coalesced events from the feature-event coalescence module, and (2) apply a series of transformations to the coalesced event data to generate a higher entropy neural code, wherein the neural code comprises a representation of ensemble activity of a plurality of neurons recorded by the system.