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1. (WO2018039642) COMPOSITIONS AND METHODS THEREOF
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Pub. No.: WO/2018/039642 International Application No.: PCT/US2017/048748
Publication Date: 01.03.2018 International Filing Date: 25.08.2017
IPC:
A61K 9/20 (2006.01) ,A61K 31/138 (2006.01) ,A61K 31/485 (2006.01) ,A61K 47/36 (2006.01) ,A61K 47/60 (2017.01) ,A61P 9/00 (2006.01) ,A61P 25/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
138
Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
[IPC code unknown for A61K 47/60]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
VEPACHEDU, Sreenivasarao [US/US]; US
EXCIVA UG (HAFTUNGSBESCHRÄNKT) [DE/DE]; Am Aukopf 14/1 69118 Heidelberg, DE
Inventors:
VEPACHEDU, Sreenivasarao; US
MOEBIUS, Hans J.; CH
BESPALOV, Anton; DE
Priority Data:
62/380,32526.08.2016US
62/477,43528.03.2017US
62/501,69604.05.2017US
Title (EN) COMPOSITIONS AND METHODS THEREOF
(FR) COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
Abstract:
(EN) Compounds of formula I, (I) or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, halogenated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N- oxides thereof, or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided. Pharmaceutical compositions comprising a compound of formula I and a compound of Formula II: (IIa) (IIb) or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof. Compositions and methods for improving the efficacy of DEX, or providing beneficial pharmacokinetic effects to DEX, comprising co-administering a compound of formula I or SARPO, and a compound of Formula II or DEX to a subject in need thereof, and dosage forms, drug delivery systems, methods of treatment thereof.
(FR) L'invention concerne des composés de formule I, (I) ou des énantiomères de ceux-ci, des métabolites de ceux-ci, des dérivés de ceux-ci, des dérivés deutérés de ceux-ci, des dérivés halogénés de ceux-ci, des promédicaments de ceux-ci, des sels de qualité pharmaceutique de ceux-ci, des N-oxydes de ceux-ci, ou une combinaison de ceux-ci, des procédés et des intermédiaires pour leur préparation, des compositions en contenant, et leurs utilisations. L'invention concerne des compositions pharmaceutiques comprenant un composé de formule I et un composé de formule II : (IIa) (IIb) ou des énantiomères de ceux-ci, des métabolites de ceux-ci, des dérivés de ceux-ci, des dérivés deutérés de ceux-ci, des promédicaments de ceux-ci, des sels de qualité pharmaceutique de ceux-ci, des N-oxydes de ceux-ci, ou une combinaison de ceux-ci. L'invention concerne des compositions et des procédés visant à améliorer l'efficacité du DEX, ou à fournir des effets pharmacocinétiques bénéfiques au DEX, comprenant la co-administration d'un composé de formule I ou SARPO, et d'un composé de formule II ou DEX à un sujet en ayant besoin, et des formes posologiques, des systèmes d'administration de médicament et des méthodes de traitement les utilisant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)