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1. (WO2018039545) BCL-W POLYPEPTIDES AND MIMETICS FOR TREATING OR PREVENTING CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY AND HEARING LOSS
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Pub. No.: WO/2018/039545 International Application No.: PCT/US2017/048582
Publication Date: 01.03.2018 International Filing Date: 25.08.2017
IPC:
A61K 45/06 (2006.01) ,A61K 31/337 (2006.01) ,C07K 14/47 (2006.01) ,A61P 25/02 (2006.01) ,A61P 25/00 (2006.01) ,A61P 27/16 (2006.01)
[IPC code unknown for A61K 45/06][IPC code unknown for A61K 31/337][IPC code unknown for C07K 14/47][IPC code unknown for A61P 25/02][IPC code unknown for A61P 25][IPC code unknown for A61P 27/16]
Applicants:
DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Avenue Boston, Massachusetts 02215-5450, US
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138-3876, US
Inventors:
SEGAL, Rosalind; US
WALENSKY, Loren D.; US
GOODRICH, Lisa Vaughn; US
RAISSI, Sarah Elizabeth; US
MURPHY, Maria F.; US
BIRD, Gregory H.; US
Agent:
KOIPALLY, Joseph J.; US
ZHANG, Tony; US
Priority Data:
62/380,04826.08.2016US
Title (EN) BCL-W POLYPEPTIDES AND MIMETICS FOR TREATING OR PREVENTING CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY AND HEARING LOSS
(FR) POLYPEPTIDES BCL-W ET MIMÉTIQUES POUR TRAITER OU PRÉVENIR UNE NEUROPATHIE PÉRIPHÉRIQUE INDUITE PAR UNE CHIMIOTHÉRAPIE ET UNE PERTE D'AUDITION
Abstract:
(EN) Compositions and methods are provided for the treatment or prevention of chemotherapy-induced peripheral neuropathy and hearing loss in a subject in need thereof. The methods involve administering to the subject a bclw protein, a BH4 domain-containing fragment thereof, or a bclw mimetic. Also provided are exemplary bclw mimetics.
(FR) L'invention concerne des compositions et des méthodes pour le traitement ou la prévention d'une neuropathie périphérique induite par une chimiothérapie et une perte d'audition chez un sujet en ayant besoin. Les méthodes consistent à administrer au sujet une protéine bclw, un fragment de celle-ci contenant un domaine BH4, ou un mimétique de bclw. L'invention concerne également des mimétiques de bclw donnés à titre d'exemple.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)