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1. (WO2018039526) TREATMENT OF NEURODEGENERATIVE DISORDERS AND PAIN

Pub. No.:    WO/2018/039526    International Application No.:    PCT/US2017/048555
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Sat Aug 26 01:59:59 CEST 2017
IPC: A61K 31/375
A61P 25/28
A61P 39/06
Applicants: WRIGHT STATE UNIVERSITY
Inventors: CORBETT, Adrian M.
Title: TREATMENT OF NEURODEGENERATIVE DISORDERS AND PAIN
Abstract:
Methods for managing pain, treating pain, and treating neurodegenerative disorders. The methods include administering to a subject in need thereof: (A) a therapeutically effective amount of simvastatin or a pharmaceutically acceptable salt thereof, (B) at least one of a therapeutically effective amount of fluoxetine racemate or a pharmaceutically acceptable salt thereof, a therapeutically effective amount of enantiopure (S)-fluoxetine or a pharmaceutically acceptable salt thereof, or a therapeutically effective amount of enantioenriched fluoxetine having an enantiomeric excess of (S)-fluoxetine or a pharmaceutically acceptable salt thereof, and (C) a therapeutically effective amount of ascorbic acid or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions for the management of pain, treatment of pain, and treatment of neurodegenerative disorders.