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1. (WO2018039463) METHODS FOR THE DETECTION OF GENOMIC COPY CHANGES IN DNA SAMPLES

Pub. No.:    WO/2018/039463    International Application No.:    PCT/US2017/048434
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Fri Aug 25 01:59:59 CEST 2017
IPC: C12Q 1/68
G06F 19/00
G06F 19/20
Applicants: RESOLUTION BIOSCIENCE, INC.
Inventors: RAYMOND, Christopher K.
LIM, Lee P.
HERNANDEZ, Jennifer
Title: METHODS FOR THE DETECTION OF GENOMIC COPY CHANGES IN DNA SAMPLES
Abstract:
The present invention includes compositions and methods useful for the detection of a mutational change, SNP, translocation, inversion, deletion, change in copy number, or other genetic variation within a sample of cellular genomic DNA or cell-free DNA (cfDNA). In some embodiments, the compositions and methods of the present invention provide an extremely high level of resolution that is particularly useful in detecting copy number variations in a small fraction of the total cfDNA from a biological sample (e.g., blood).