Search International and National Patent Collections

1. (WO2018039452) METHODS OF TREATING CANCERS WITH CHEMOTHERAPY WITH REDUCED TOXICITY

Pub. No.:    WO/2018/039452    International Application No.:    PCT/US2017/048415
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Fri Aug 25 01:59:59 CEST 2017
IPC: A61K 39/395
C07K 16/00
Applicants: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
KY, Bonnie
Inventors: KY, Bonnie
SPEICHER, David, W.
Title: METHODS OF TREATING CANCERS WITH CHEMOTHERAPY WITH REDUCED TOXICITY
Abstract:
In some embodiments, therapeutic treatments for a disease such as a cancer are disclosed, including pharmaceutical compositions and methods of using pharmaceutical compositions for treating a cancer in a human subject wherein the human subject exhibits an elevated concentration of immunoglobulin E (IgE) in plasma obtained from the human subject, comprising the step of administering a therapeutically effective amount of a chemotherapeutic regimen to the human subject in need thereof. In some embodiments, the chemotherapeutic regimen includes doxorubicin monotherapy, trastuzumab monotherapy, doxorubicin and trastuzumab combination therapy, doxorubicin, cyclophosphamide, and 5-fluorouracil combination therapy, and doxorubicin, cyclophosphamide, paclitaxel, and trastuzumab combination therapy.