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1. (WO2018039448) ENGINEERED TARGET SPECIFIC NUCLEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/039448    International Application No.:    PCT/US2017/048409
Publication Date: 01.03.2018 International Filing Date: 24.08.2017
IPC:
C12N 9/14 (2006.01), C12N 9/22 (2006.01), A61K 38/16 (2006.01)
Applicants: SANGAMO THERAPEUTICS, INC. [US/US]; 501 Canal Blvd., Suite A100 Richmond, California 94804 (US)
Inventors: MILLER, Jeffrey C.; (US).
REBAR, Edward J.; (US)
Agent: PASTERNAK, Dahna; (US)
Priority Data:
62/378,978 24.08.2016 US
62/443,981 09.01.2017 US
Title (EN) ENGINEERED TARGET SPECIFIC NUCLEASES
(FR) NUCLÉASES SPÉCIFIQUES DE CIBLE SPÉCIFIQUEMENT MODIFIÉES
Abstract: front page image
(EN)Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.
(FR)L'invention concerne des nucléases spécifiquement modifiées comprenant des mutations dans le domaine de clivage (par exemple, FokI ou un homologue de celui-ci) et/ou un domaine de liaison à l'ADN (protéine en doigt de zinc, TALE, ARN guide unique) de telle sorte qu'une spécificité sur la cible se trouve augmentée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)