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1. (WO2018039422) NON-INVASIVE DETECTION OF BARRETT'S ESOPHAGUS

Pub. No.:    WO/2018/039422    International Application No.:    PCT/US2017/048357
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Fri Aug 25 01:59:59 CEST 2017
IPC: C12Q 1/68
G01N 33/574
Applicants: BERN, M. Jonathan
Inventors: BERN, M. Jonathan
Title: NON-INVASIVE DETECTION OF BARRETT'S ESOPHAGUS
Abstract:
An office based non-invasive screening test for detection of Barrett's esophagus (BE) is disclosed. Over expression of specific molecular target molecules is used for the diagnosis of BE. In certain embodiments, the molecular targets are detected by quantitative reverse transcriptase PCR (RT-qPCR). In certain embodiments, a diagnostic test is provided that includes collection of esophageal brushings and testing for expression of one or more of MUC2 and CDX2, wherein expression of MUC2 and/or CDX2 in the esophagus is diagnostic for Barrett's esophagus. In certain embodiments, the diagnostic test may also utilize and immunoassay to determine MUC2 protein concentrations to establish the diagnosis of Barrett's esophagus.