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1. (WO2018039333) TIM3 HOMING ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE

Pub. No.:    WO/2018/039333    International Application No.:    PCT/US2017/048197
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Thu Aug 24 01:59:59 CEST 2017
IPC: C12N 15/87
C12N 15/63
Applicants: BLUEBIRD BIO, INC.
Inventors: HAVENS, Kyle
JARJOUR, Jordan
Title: TIM3 HOMING ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE
Abstract:
The invention provides improved genome editing compositions and methods for editing a TIM3 gene. The invention further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.