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1. (WO2018039232) METHODS FOR CROSS COUPLING

Pub. No.:    WO/2018/039232    International Application No.:    PCT/US2017/048021
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Wed Aug 23 01:59:59 CEST 2017
IPC: C07F 5/04
C07C 13/36
C07C 67/333
C07C 69/753
C07D 213/26
C07D 239/26
C07D 263/56
C07D 413/08
C07F 5/02
Applicants: ZENO ROYALTIES & MILESTONES, LLC
Inventors: PINCHMAN, Joseph Robert
HOPKINS, Chad Daniel
BUNKER, Kevin Duane
HUANG, Peter Qinhua
Title: METHODS FOR CROSS COUPLING
Abstract:
Methods of preparing substituted bicyclo[1.1.1]pentane compounds of Formula (I) comprise reacting a compound of Formula (A) with a compound of Formula (B) in the presence of a first transition metal catalyst selected from a palladium catalyst and a nickel catalyst, where the variables R1, R2, X1 and X2 are as described herein.