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1. (WO2018039232) METHODS FOR CROSS COUPLING
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/039232 International Application No.: PCT/US2017/048021
Publication Date: 01.03.2018 International Filing Date: 22.08.2017
IPC:
C07F 5/04 (2006.01) ,C07C 13/36 (2006.01) ,C07C 67/333 (2006.01) ,C07C 69/753 (2006.01) ,C07D 213/26 (2006.01) ,C07D 239/26 (2006.01) ,C07D 263/56 (2006.01) ,C07D 413/08 (2006.01) ,C07F 5/02 (2006.01)
Applicants: KALYRA PHARMACEUTICALS, INC.[US/US]; 10835 Road to the Cure Suite 205 San Diego, California 92121, US
Inventors: PINCHMAN, Joseph Robert; US
HOPKINS, Chad Daniel; US
BUNKER, Kevin Duane; US
HUANG, Peter Qinhua; US
Agent: MILLER, Kimberly J.; US
Priority Data:
62/378,45323.08.2016US
Title (EN) METHODS FOR CROSS COUPLING
(FR) PROCÉDÉS DE COUPLAGE CROISÉ
Abstract:
(EN) Methods of preparing substituted bicyclo[1.1.1]pentane compounds of Formula (I) comprise reacting a compound of Formula (A) with a compound of Formula (B) in the presence of a first transition metal catalyst selected from a palladium catalyst and a nickel catalyst, where the variables R1, R2, X1 and X2 are as described herein.
(FR) La présente invention concerne des procédés de préparation de composés bicyclo[1.1.1]pentane substitués de formule (I) comprenant la réaction d'un composé de formule (A) avec un composé de formule (B) en présence d'un premier catalyseur de métal de transition choisi parmi un catalyseur au palladium et un catalyseur au nickel, où les variables R 1 , R 2 , X 1 et X 2 sont tels que décrits ici.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)