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1. WO2018039197 - ALDEHYDE TRAPPING COMPOUNDS AND METHODS OF USE THEREOF

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Publication Number WO/2018/039197
Publication Date 01.03.2018
International Application No. PCT/US2017/047958
International Filing Date 22.08.2017
IPC
A61K 31/423 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
C07D 215/38 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07D 213/73
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
73Unsubstituted amino or imino radicals
C07D 215/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
C07D 241/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
36condensed with carbocyclic rings or ring systems
38with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
40Benzopyrazines
44with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 261/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
261Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
20condensed with carbocyclic rings or ring systems
C07D 263/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
56with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
Applicants
  • ALDEYRA THERAPEUTICS, INC. [US]/[US]
Inventors
  • KINNEY, William A.
  • MACHATHA, Stephen Gitu
  • YOUNG, Scott
Agents
  • REID, Andrea L.C.
  • ARICO, Joseph W.
  • FLEMING, Paul R.
  • SCALTRITO, Donald V.
  • OH, Euk Charlie
  • NIHAN, Danielle M.
  • DECHERT LLP
Priority Data
62/378,04622.08.2016US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ALDEHYDE TRAPPING COMPOUNDS AND METHODS OF USE THEREOF
(FR) COMPOSÉS DE PIÉGEAGE D'ALDÉHYDES ET LEURS PROCÉDÉS D'UTILISATION
front page image
Abstract
(EN) The present invention provides compounds and methods for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
(FR) La présente invention concerne des composés et des procédés pour le traitement, la prévention et/ou la réduction d'un risque d'une maladie, d'un trouble ou d'un état où une toxicité d'aldéhydes est impliquée dans la pathogenèse, comprenant des troubles oculaires, des troubles cutanés, des états associés aux effets nocifs d'agents vésicants, et des maladies auto-immunes, inflammatoires, neurologiques et cardiovasculaires, au moyen d'une amine primaire pour piéger des aldéhydes toxiques, comme le MDA et le HNE.
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