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1. (WO2018039197) ALDEHYDE TRAPPING COMPOUNDS AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/039197    International Application No.:    PCT/US2017/047958
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Wed Aug 23 01:59:59 CEST 2017
IPC: A61K 31/423
C07D 215/38
Applicants: ALDEYRA THERAPEUTICS, INC.
Inventors: KINNEY, William A.
MACHATHA, Stephen Gitu
YOUNG, Scott
Title: ALDEHYDE TRAPPING COMPOUNDS AND METHODS OF USE THEREOF
Abstract:
The present invention provides compounds and methods for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.