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1. (WO2018039192) ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/039192    International Application No.:    PCT/US2017/047945
Publication Date: 01.03.2018 International Filing Date: 22.08.2017
IPC:
A61K 31/423 (2006.01), C07D 215/38 (2006.01)
Applicants: ALDEYRA THERAPEUTICS, INC. [US/US]; 131 Hartwell Avenue, Suite 320 Lexington, Massachusetts 02421 (US)
Inventors: MACHATHA, Stephen Gitu; (US).
YOUNG, Scott; (US)
Agent: REID, Andrea L.C.; (US).
ARICO, Joseph W.; (US).
FLEMING, Paul R.; (US).
SCALTRITO, Donald V.; (US).
OH, Euk Charlie; (US).
NIHAN, Danielle M.; (US)
Priority Data:
62/378,065 22.08.2016 US
Title (EN) ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS DE PIÉGEAGE D'ALDÉHYDES ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides compounds and methods for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
(FR)La présente invention concerne des composés et des procédés pour le traitement, la prévention et/ou la réduction d'un risque d'une maladie, d'un trouble ou d'un état dans lequel la toxicité d'aldéhydes est impliquée dans la pathogenèse, comprenant des troubles oculaires, des troubles cutanés, des états associés aux effets nocifs d'agents vésicants, et des maladies auto-immunes, inflammatoires, neurologiques et cardiovasculaires, par l'utilisation d'une amine primaire pour piéger des aldéhydes toxiques, comme le MDA et le HNE.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)