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1. (WO2018039185) METHODS AND MATERIALS FOR TREATING ESTROGEN RECEPTOR POSITIVE BREAST CANCER
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Pub. No.: WO/2018/039185 International Application No.: PCT/US2017/047937
Publication Date: 01.03.2018 International Filing Date: 22.08.2017
IPC:
C12Q 1/68 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH [US/US]; 200 First Street S.W. Rochester, Minnesota 55905, US
Inventors:
DUDENKOV, Tanda T.; US
WANG, Liewei; US
INGLE, James N.; US
WEINSHILBOUM, Richard M.; US
CAIRNS, Junmei; US
Agent:
FINN III, J. Patrick; US
Priority Data:
62/378,56923.08.2016US
Title (EN) METHODS AND MATERIALS FOR TREATING ESTROGEN RECEPTOR POSITIVE BREAST CANCER
(FR) PROCÉDÉS ET MATÉRIAUX DE TRAITEMENT DU CANCER DU SEIN POSITIF AUX RÉCEPTEURS DES ŒSTROGÈNES
Abstract:
(EN) This document provides methods and materials for treating cancer (e.g., estrogen receptor positive breast cancer). For example, methods and materials for identifying a mammal (e.g., a human) with cancer (e.g., estrogen receptor positive breast cancer) as having A→G variant genotype of rs6990851 and/or as having an elevated level of CSMD1 nucleic acid expression and administering one or more aromatase inhibitors (e.g., anastrozole) to treat the mammal identified as having such genotype and/or elevated level are provided.
(FR) La présente invention concerne des procédés et des matériaux de traitement du cancer (par exemple le cancer du sein positif aux récepteurs des œstrogènes). Par exemple, l'invention concerne des procédés et des matériaux d’identification d’un mammifère (par exemple un être humain) souffrant d'un cancer (par exemple le cancer du sein positif aux récepteurs des œstrogènes) comme ayant un génotype variant A→G de rs6990851 et/ou comme présentant un niveau élevé d’expression des acides nucléiques CSMD1, et l’administration d’un ou de plusieurs inhibiteurs de l’aromatase (par exemple l’anastrozole) afin de traiter le mammifère identifié comme ayant un tel génotype et/ou un niveau élevé.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)