Search International and National Patent Collections

1. (WO2018039147) THERAPEUTIC USES OF LAG3 THE α-SYNUCLEIN TRANSMISSION RECEPTOR

Pub. No.:    WO/2018/039147    International Application No.:    PCT/US2017/047878
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Wed Aug 23 01:59:59 CEST 2017
IPC: A61K 38/00
A61K 48/00
A61P 25/16
A61P 25/28
Applicants: THE JOHNS HOPKINS UNIVERSITY
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors: DAWSON, Ted M.
DAWSON, Valina L.
KO, Han Seok
MAO, Xiaobo
ALBERTO VIGNALI, Dario Angelo
WORKMAN, Creg J.
Title: THERAPEUTIC USES OF LAG3 THE α-SYNUCLEIN TRANSMISSION RECEPTOR
Abstract:
Described are methods of inhibiting neurodegeneration in a subject by administering to the subject an agent that prevents (alpha)-syn PFF from binding to its receptor. The agent may be a small molecule chemical compound, antibody, nucleic acid molecule, or polypeptide. Drug screening methods are also provided.