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|1. (WO2018039139) HYDROGEL PLATFORM FOR AQUEOUS TWO-PHASE CONCENTRATION OF A TARGET TO ENHANCE ITS DETECTION|
|Applicants:||THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|Inventors:||KAMEI, Daniel Takashi
WU, Benjamin Ming
PEREIRA, David Yuan
WU, Chloe Michelle
YEE, Matthew Foosing
KEEFE, Joshua Anthony
PEARCE, Christina Caroline
DAILAMY, Amir Adam
WONG, Vincent K.
LE, Nguyen Khoi
|Title:||HYDROGEL PLATFORM FOR AQUEOUS TWO-PHASE CONCENTRATION OF A TARGET TO ENHANCE ITS DETECTION|
It was discovered that hydrogel scaffolds can be used to induce phase separation as aqueous two-phase systems (ATPSs) pass through and/or rehydrate the scaffolds, allowing for concentration of target analyte(s) (e.g., biomolecule(s)) into a particular phase of the ATPS or into a leading front. Accordingly, in various embodiments methods and devices are provided that utilize aqueous two-phase systems and hydrogel scaffolds to improve the sensitivity of assays (e.g., of point-of-care assays) without sacrificing cost or ease of use.