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1. (WO2018039129) NON-HYDROGEN-BONDING UNIVERSAL READER FOR DNA SEQUENCING

Pub. No.:    WO/2018/039129    International Application No.:    PCT/US2017/047818
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Tue Aug 22 01:59:59 CEST 2017
IPC: G01N 27/26
G01N 27/60
Applicants: ZHANG, Peiming
BISWAS, Sovan
SEN, Suman
LINDSAY, Stuart
Inventors: ZHANG, Peiming
BISWAS, Sovan
SEN, Suman
LINDSAY, Stuart
Title: NON-HYDROGEN-BONDING UNIVERSAL READER FOR DNA SEQUENCING
Abstract:
The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids.