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1. (WO2018039119) METHODS OF SUPPRESSING DELIVERY OF EXOSOMES TO LIVER AND SPLEEN

Pub. No.:    WO/2018/039119    International Application No.:    PCT/US2017/047794
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Tue Aug 22 01:59:59 CEST 2017
IPC: A61K 9/10
A61K 35/12
A61K 48/00
C12N 15/88
Applicants: CODIAK BIOSCIENCES, INC.
Inventors: WILLIAMS, Douglas, E.
KULMAN, John, D.
Title: METHODS OF SUPPRESSING DELIVERY OF EXOSOMES TO LIVER AND SPLEEN
Abstract:
The instant application describes improved methods and compositions for the systemic delivery of therapeutic exosomes to a subject in need thereof. In certain embodiments, the current invention reduces the amount of exosomes delivered to liver, spleen and combinations thereof to allow greater distribution to other areas of the body such as, but not limited to, the brain, pancreas, lung, kidney, muscle. In certain embodiments, the methods involve the injection of one or multiple doses of non-therapeutic exosomes prior to the injection of a suitable therapeutic dose of exosomes with a therapeutic payload. Also included are methods to improve immune clearance of exosomes in subjects by inhibiting phagocytosis.