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1. (WO2018039093) CONTAINER SYSTEM AND METHOD FOR FREEZING AND THAWING A LIQUID PRODUCT

Pub. No.:    WO/2018/039093    International Application No.:    PCT/US2017/047714
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Tue Aug 22 01:59:59 CEST 2017
IPC: B65D 81/00
Applicants: MERCK SHARP & DOHME CORP.
JOHNSON, Jeffrey Charles
FLAMMINO, Anthony
PETRICH, Mark Anton
MCFEATERS, Scott
ROOSA, John, H., Jr.
ALPERN, Robert Ian
LOCURCIO, Joseph, W.
FLAMM, Matthew, H.
Inventors: JOHNSON, Jeffrey Charles
FLAMMINO, Anthony
PETRICH, Mark Anton
MCFEATERS, Scott
ROOSA, John, H., Jr.
ALPERN, Robert Ian
LOCURCIO, Joseph, W.
FLAMM, Matthew, H.
Title: CONTAINER SYSTEM AND METHOD FOR FREEZING AND THAWING A LIQUID PRODUCT
Abstract:
Container system and method for freezing (and subsequently thawing) a liquid such as a drug substance, such that all containers in a set have a uniform width, hence uniform freeze-path length, in the widthwise direction and perpendicular to major walls of the containers, irrespective of the particular length, height, and volumetric capacity of the various containers in the set. This leads to uniform freezing performance and thereby reduces cryoconcentration. The system also eliminates or reduces ice-bridging, and the potential for containers rupturing during freezing and thawing operations.