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1. (WO2018039090) METHODS OF USE & COMPOSITIONS OF IBD, IBS, & ANTINEOPLASTIC MICROBIAL THERAPEUTICS
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Pub. No.: WO/2018/039090 International Application No.: PCT/US2017/047706
Publication Date: 01.03.2018 International Filing Date: 20.08.2017
IPC:
A61K 31/739 (2006.01) ,A61K 35/74 (2015.01) ,A61K 39/00 (2006.01) ,A61K 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
739
Lipopolysaccharides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
74
Bacteria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
Applicants:
GREGG, John, Maicolm Hall [US/US]; US
Inventors:
GREGG, John, Maicolm Hall; US
Priority Data:
64/494,76320.08.2016US
Title (EN) METHODS OF USE & COMPOSITIONS OF IBD, IBS, & ANTINEOPLASTIC MICROBIAL THERAPEUTICS
(FR) PROCÉDÉS D'UTILISATION DE COMPOSITIONS PHARMACEUTIQUES D'AGENTS THÉRAPEUTIQUES MICROBIENS ANTINÉOPLASIQUES, IBD ET IBS.
Abstract:
(EN) This invention relates to the medical use of pathogen associated molecular pattern (PAMP) displaying immunostimulatory microbial immuno-adjuvants [MIAs], as therapeutics when used in combination with check point inhibitors to treat various types of cancer and to methods of treatment which involve treating a subject with these compounds and compound mixtures and process methods for identifying and optimally composing them for their therapeutic use in cancer treatment. It also relates to the use of inhibitors of these PAMP displaying immunostimulatory microbial immuno-adjuvants [MIAs], as therapeutics when used to treat inflammatory bowel disease (IBD) including Crohn's Disease and ulcerative colitis and irritable bowel syndrome (IBS) and process methods for identifying and optimally composing them for their therapeutic use in IBD and IBS.
(FR) La présente invention concerne l'utilisation médicale d'un motif moléculaire associé à un agent pathogène (PAMP) affichant des immunoadjuvants microbiens immunostimulateurs [MIAs], en tant qu'agents thérapeutiques lorsqu'ils sont utilisés en combinaison avec des inhibiteurs de points de contrôle pour traiter divers types de cancer ainsi que des procédés de traitement qui impliquent le traitement d'un sujet avec ces composés et mélanges de composés et des procédés pour les identifier et les composer de manière optimale pour leur utilisation thérapeutique dans le traitement du cancer. L'invention concerne également l'utilisation d'inhibiteurs de ces PAMP affichant des immuno-adjuvants microbiens immunostimulateurs [MIAs], en tant qu'agents thérapeutiques lorsqu'ils sont utilisés pour traiter une maladie intestinale inflammatoire (IBD) y compris la maladie de Crohn et la colite ulcéreuse et le syndrome du côlon irritable (IBS), et des procédés pour identifier et composer de manière optimale ceux-ci pour leur utilisation thérapeutique dans les IBD et IBD.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)