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1. (WO2018039087) ANTIMICROBIAL DRUG METHODS OF USE & THERAPEUTIC COMPOSITIONS

Pub. No.:    WO/2018/039087    International Application No.:    PCT/US2017/047701
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Sun Aug 20 01:59:59 CEST 2017
IPC: A61K 31/4164
A61K 31/56
A61P 31/00
A61P 31/04
A61K 9/22
A61K 45/00
Applicants: GREGG, John, Malcolm Hall
Inventors: GREGG, John, Malcolm Hall
Title: ANTIMICROBIAL DRUG METHODS OF USE & THERAPEUTIC COMPOSITIONS
Abstract:
This invention relates to the medical use of an antimicrobial agent, racemic Ornidazole, its (R) and (S) enantiomers, or pharmaceutically acceptable salts or esters thereof, and to methods of treatment which involve treating a subject with Ornidazole. The racemic (rac)-ornidazole, its enantiomers, or pharmaceutically acceptable salts or esters thereof, may be used in combination with other actives, and in particular, beta lactam antibiotics combined with beta lactamase inhibitors, like co-amoxiclav. The invention also relates to pharmaceutical formulations and compositions comprising (rac)-ornidazole, (R)- ornidazole, (S)-ornidazole, or pharmaceutically acceptable salts or esters thereof, and/or other actives and their use with bio-threat pathogens that utilize a mechanism of tolerance or resistance by facultatively switching from aerobic to anaerobic confirmations and by switching back and forth from planktonic to biofilm forms.