Search International and National Patent Collections

1. (WO2018039068) METHODS AND COMPOSITIONS RELATED TO IN VIVO SELECTION OF FUNCTIONAL MOLECULES

Pub. No.:    WO/2018/039068    International Application No.:    PCT/US2017/047585
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Sat Aug 19 01:59:59 CEST 2017
IPC: A61K 35/28
C07K 16/28
G01N 33/50
Applicants: THE SCRIPPS RESEARCH INSTITUTE
Inventors: HAN, Kyung, Ho
LERNER, Richard, A.
Title: METHODS AND COMPOSITIONS RELATED TO IN VIVO SELECTION OF FUNCTIONAL MOLECULES
Abstract:
The Invention provides in vivo selection methods for identifying modulating agents (e.g., antibodies or polypeptides) that promote cellular differentiation and migration. The methods utilize a combinatorial agent library (e.g., antibodies expressed via lentiviral vectors) that are expressed in a population of to-be modulated cells (e.g., stem cells), which are then introduced into, the body of a non-hum an animal (e.g., mouse). This is followed by examining an organ or tissue of interest (e.g., brain) of the manipulated animal for the presence of a modulating agent and/or a specific phenotype. The; invention also provides specific antibody agent, that can induce differentiation of stem cells into microglia and migration into the brain. Further provided in the invention are therapeutic applications of the microglia-inducing antibodies.