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1. (WO2018039030) METHODS FOR DETECTING AND/OR PREDICTING AGE-RELATED MACULAR DEGENERATION AND/OR ALZHEIMER'S DISEASE
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Pub. No.: WO/2018/039030 International Application No.: PCT/US2017/047323
Publication Date: 01.03.2018 International Filing Date: 17.08.2017
IPC:
G01N 33/58 (2006.01) ,G01N 33/533 (2006.01) ,A61K 49/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58
involving labelled substances
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
531
Production of immunochemical test materials
532
Production of labelled immunochemicals
533
with fluorescent label
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
Applicants:
UNIVERSITY OF MARYLAND, BALTIMORE [US/US]; 620 West Lexington Street, 4th Floor Baltimore, MD 21201, US
UCL BUSINESS PLC [GB/GB]; The Network Building 97 Tottenham Road London W1T 4TB, GB
Inventors:
THOMPSON, Richard; US
ZENG, Hui, Hui; US
SZMACINSKI, Henryk; US
LENGYEL, Imre; NF
Agent:
FUIERER, Marianne; MOORE & VAN ALLEN, PLLC P. O. BOX 13706 Research Triangle Park, NC 27709, US
Priority Data:
62/378,26823.08.2016US
Title (EN) METHODS FOR DETECTING AND/OR PREDICTING AGE-RELATED MACULAR DEGENERATION AND/OR ALZHEIMER'S DISEASE
(FR) PROCÉDÉS DE DÉTECTION ET/OU DE PRÉDICTION DE LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L'ÂGE ET/OU DE LA MALADIE D'ALZHEIMER
Abstract:
(EN) The present invention provides for the use of hydroxyapatite-selective fluorescent dyes in combination with fluorescence lifetime imaging to detect any hydroxyapatite spherules or hydroxyapatite deposits in the retina tissue of a subject, including the peripheral or macula tissue, wherein the hydroxyapatite spherules or hydroxyapatite deposits initiate or support the growth of sub-RPE deposits and correlates with age-related macular degeneration and/or Alzheimer's disease.
(FR) La présente invention concerne l'utilisation de colorants fluorescents sélectifs de l'hydroxyapatite en combinaison avec une imagerie de durée de vie de fluorescence pour détecter toute sphérule d'hydroxyapatite ou tout dépôt d'hydroxyapatite dans le tissu rétinien d'un sujet, y compris le tissu périphérique ou de la macula, les sphérules d'hydroxyapatite ou les dépôts d'hydroxyapatite initiant ou favorisant la croissance de dépôts de sous l'épithélium pigmentaire et étant corrélés à la dégénérescence maculaire liée à l'âge et/ou la maladie d'Alzheimer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)