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1. (WO2018038973) NEUROPROTECTIVE BETA AMYLOID CORE PEPTIDES AND PEPTIDOMIMETIC DERIVATIVES
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Pub. No.: WO/2018/038973 International Application No.: PCT/US2017/046953
Publication Date: 01.03.2018 International Filing Date: 15.08.2017
IPC:
A61K 38/00 (2006.01) ,A61K 38/04 (2006.01) ,A61P 25/28 (2006.01) ,C07K 7/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
Applicants:
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US/US]; The University of Arizona, Tech Transfer Arizona University Services Annex, 4th Floor P.O. Box 210300A Tucson, AZ 85721, US
UNIVERSITY OF HAWAII [US/US]; 2425 Campus Road, Sinclair 10 Honolulu, HI 96822, US
Inventors:
NICHOLS, Robert, A.; US
FOREST, Kelly; US
HRUBY, Victor, J.; US
Agent:
NGUYEN, Quan; US
Priority Data:
62/377,55620.08.2016US
Title (EN) NEUROPROTECTIVE BETA AMYLOID CORE PEPTIDES AND PEPTIDOMIMETIC DERIVATIVES
(FR) PEPTIDES DE NOYAU BÊTA-AMYLOÏDE NEUROPROTECTEURS ET DÉRIVÉS PEPTIDOMIMÉTIQUES
Abstract:
(EN) Peptide analogues of β-amyloid and methods of using said analogues for neuroprotection are described herein. The β-amyloid peptide analogues have a sequence that is at least 50% identical to an N-terminal β-amyloid core fragment. A pharmaceutical composition of the β-amyloid peptide analogues in a pharmaceutically acceptable carrier can be administered to a subject for neuromodulation. The β-amyloid peptide analogues, while lacking neurotoxicity, effectively provides for protective activity against β-amyloid toxicity.
(FR) L'invention concerne des analogues peptidiques du bêta-amyloïde et des procédés d'utilisation desdits analogues pour la neuroprotection. Les analogues du peptide ß-amyloïde ont une séquence qui est identique d'au moins 50 % à un fragment n-terminal du noyau ß-amyloïde. Une composition pharmaceutique des analogues de peptide bêta-amyloïde dans un véhicule pharmaceutiquement acceptable peut être administrée à un sujet en vue d'une neuromodulation. Ces analogues du peptide ß-amyloïde, tout en ne présentant pas de neurotoxicité, permettent efficacement une activité protectrice contre la toxicité de la bêta-amyloïde.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)