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1. (WO2018038966) PHARMACEUTICAL COMPOSITIONS FOR INDUCING PHENOTYPIC REVERSION OF A CELL AND REGENERATION OF COMPROMISED TISSUE
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Pub. No.: WO/2018/038966 International Application No.: PCT/US2017/046881
Publication Date: 01.03.2018 International Filing Date: 15.08.2017
IPC:
A61K 31/573 (2006.01) ,A61K 47/12 (2006.01) ,A61K 38/28 (2006.01) ,A61K 9/08 (2006.01) ,A61P 21/00 (2006.01) ,A61P 27/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01) ,A61P 17/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57
substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573
substituted in position 21, e.g. cortisone, dexamethasone, prednisone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
28
Insulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
14
for baldness or alopecia
Applicants:
PAZ GARCIA, Juan [MX/MX]; MX
PAZ MICHEL, Brenda, Astrid [MX/US]; US
Inventors:
PAZ GARCIA, Juan; MX
PAZ MICHEL, Brenda, Astrid; US
Agent:
ADLER, Benjamin, Aaron; US
Priority Data:
15/238,29226.08.2016US
Title (EN) PHARMACEUTICAL COMPOSITIONS FOR INDUCING PHENOTYPIC REVERSION OF A CELL AND REGENERATION OF COMPROMISED TISSUE
(FR) COMPOSITIONS PHARMACEUTIQUES POUR INDUIRE UNE RÉVERSION PHÉNOTYPIQUE D'UNE CELLULE ET LA RÉGÉNÉRATION DE TISSU COMPROMIS
Abstract:
(EN) The present invention provides a pharmaceutical composition comprising a formulation of a corticosteroid and at least one organic acid and, optionally, a fast-acting insulin analog, in a vehicle. Also provided are methods to induce the phenotypic reversion of a tumor cell or cystic cell, to induce regeneration of a tissue in a subject and to treat tumors and/or cysts of the jaw in a subject with the pharmaceutical compositions and formulations described herein.
(FR) La présente invention concerne une composition pharmaceutique comprenant une formulation d'un corticostéroïde et d'au moins un acide organique et, éventuellement, un analogue d'insuline à action rapide, dans un véhicule. L'invention concerne également des procédés pour induire la réversion phénotypique d'une cellule tumorale ou d'une cellule kystique, pour induire la régénération d'un tissu chez un sujet et pour traiter des tumeurs et/ou des kystes de la mâchoire chez un sujet avec les compositions pharmaceutiques et les formulations décrites ici.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)