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1. (WO2018038684) MACROPHAGE STIMULATING PROTEIN RECEPTOR (OR RON - RECEPTEUR D' ORIGINE NANTAIS) ANTIBODIES AND USES THEREOF
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Pub. No.: WO/2018/038684 International Application No.: PCT/SG2017/050424
Publication Date: 01.03.2018 International Filing Date: 28.08.2017
Chapter 2 Demand Filed: 26.06.2018
IPC:
C07K 16/30 (2006.01) ,A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,G01N 33/53 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way #20-10 Connexis North Tower, Singapore 138632, SG
Inventors:
LANE, David; SG
KOH, Xin Yu; SG
HWANG, Le-Ann; SG
Agent:
SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office Singapore 903031, SG
Priority Data:
10201607147P26.08.2016SG
10201700393P17.01.2017SG
10201700521V20.01.2017SG
10201703234U19.04.2017SG
Title (EN) MACROPHAGE STIMULATING PROTEIN RECEPTOR (OR RON - RECEPTEUR D' ORIGINE NANTAIS) ANTIBODIES AND USES THEREOF
(FR) ANTICORPS DU RÉCEPTEUR DE LA PROTÉINE STIMULANT LES MACROPHAGES (OU DU RON-RÉCEPTEUR D'ORIGINE NANTAIS) ET LEURS UTILISATIONS
Abstract:
(EN) Disclosed are monoclonal antibodies that bind specifically to macrophage stimulating protein receptor (or RON - Recepteur d' Origine Nantais). Also provided are the chimeric antigen receptors, bispecific antibodies, bivalent antibodies and biTE thereof, as well as pharmaceutical compositions and uses of said antibodies for the treatment of cancer and fibrosis and an ex vivo method of evaluating the status of a cancer patient using said antibodies. In particular, two monoclonal antibodies, 7G8 and 6D4, demonstrating good therapeutic efficacy in inhibiting tumour growth in human xenograft mice models and sensitivity in human xenograft mouse tumour imaging models are provided.
(FR) L'invention concerne des anticorps monoclonaux qui se lient spécifiquement au récepteur de protéine stimulant les macrophages (ou RON-récepteur d'Origine Nantais). L'invention concerne également les récepteurs antigéniques chimériques, les anticorps bispécifiques, les anticorps bivalents et le biTE de ceux-ci, ainsi que des compositions pharmaceutiques et des utilisations desdits anticorps pour le traitement du cancer et de la fibrose et d'un procédé ex vivo d'évaluation de l'état d'un patient cancéreux à l'aide desdits anticorps. En particulier, l'invention concerne deux anticorps monoclonaux, 7G8 et 6D4, présentant une bonne efficacité thérapeutique dans l'inhibition de la croissance tumorale dans des modèles de souris de xénogreffe humaine et la sensibilité dans des modèles d'imagerie de tumeur de xénogreffe humaine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)