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1. (WO2018038680) PROCESSES FOR PREPARING OLAPARIB
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Pub. No.: WO/2018/038680 International Application No.: PCT/SG2017/050402
Publication Date: 01.03.2018 International Filing Date: 11.08.2017
IPC:
C07D 403/10 (2006.01) ,A61K 31/502 (2006.01)
[IPC code unknown for C07D 403/10][IPC code unknown for A61K 31/502]
Applicants:
SCINOPHARM TAIWAN, LTD.; No. 1, Nan-Ke 8th Road, Southern Taiwan Science Park, Shan-Hua, Tainan, 74144, TW
SCINOPHARM SINGAPORE PTE, LTD. [SG/SG]; 50, Raffles Place #06-00, Singapore Land Tower, Singapore 048623, SG (SG)
Inventors:
HSIAO, Tsung-Yu; TW
CHANG, Yung-Hung; TW
Agent:
MATTEUCCI, Gianfranco; SG
Priority Data:
62/379,02624.08.2016US
Title (EN) PROCESSES FOR PREPARING OLAPARIB
(FR) PROCÉDÉS DE PRÉPARATION D'OLAPARIB
Abstract:
(EN) Provided herein are novel processes and methods for making 4-[(3-[(4-cyclopropylcarbonyl)piperazin-1-yl]carbonyl)-4-fluorophenyl]methyl(2H)phthalazin-1-one (Olaparib) and intermediates thereof. Olaparib is a poly ADP ribose polymerase (PARP) inhibitor useful in the treatment of of cancers. Benefits of the present disclosure include the use of less toxic compounds and improved yields.
(FR) L'invention concerne de nouveaux procédés et de nouvelles méthodes de fabrication de 4-[(3-[(4-cyclopropylcarbonyl)pipérazin-1-yl]carbonyl)-4-fluorophényl]méthyl(2H)phtalazin-1-one (Olaparib) et des intermédiaires de ceux-ci. L'Olaparib est un inhibiteur de la poly ADP-ribose polymérase (PARP) utile dans le traitement de cancers. Les avantages de la présente invention comprennent l'utilisation de composés moins toxiques et des rendements améliorés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)