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1. (WO2018038668) RESPIRATORY SYNCYTIAL VIRUS INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/038668    International Application No.:    PCT/SE2017/050847
Publication Date: 01.03.2018 International Filing Date: 23.08.2017
IPC:
C07D 471/20 (2006.01), A61K 31/501 (2006.01), A61P 31/14 (2006.01), C07D 237/04 (2006.01), C07D 401/14 (2006.01), C07D 487/10 (2006.01)
Applicants: MEDIVIR AB [SE/SE]; Box 1086 141 22 Huddinge (SE)
Inventors: AYESA, Susana; (SE).
BYLUND, Johan; (SE).
ERSMARK, Karolina; (SE).
SALVADOR ODEN, Lourdes; (SE)
Agent: ZACCO SWEDEN AB; P.O. Box 5581 SE-114 5 Stockholm (SE)
Priority Data:
1651151-1 25.08.2016 SE
Title (EN) RESPIRATORY SYNCYTIAL VIRUS INHIBITORS
(FR) INHIBITEURS DU VIRUS RESPIRATOIRE SYNCYTIAL
Abstract: front page image
(EN)Compounds of Formula (I): wherein W is NR1A or CR1BR1B; Z is N or CH, R1A is C1-C3alkyl, C1-C3haloalkyl, C3-C4cycloalkyl or phenyl wherein cycloalkyl or phenyl is optionally mono-, di- or tri-substituted with substituents each independently selected from C1- C3alkyl, halo, amino and C1-C3alkoxy; the two R1B together with the carbon atom to which they are attached combine and form C3- C6cycloalkyl or heterocyclyl, wherein the cycloalkyl is substituent with C(=O)OR1C, NHC(=O)OR1C or NHS(=O)2 R1C, and the heterocyclyl is substituent with C(=O)R1C, C(=O)OR1C, S(=O)2 R1C, C(=O)NH2 or C(=O)NR1CR1C'; q, n, R1C, R2 and R3 are as defined herein, their use as inhibitors of RSV and related aspects.
(FR)La présente invention concerne des composés de formule (I): où W est NR1A ou CR1BR1B; Z est N ou CH, R1A est un alkyle C1-C3, un haloalkyl C1-C3, un cycloalkyle C3-C4 ou un phényle où le cycloalkyle ou le phényle est facultativement mono-, bi-, ou tri-substitué avec des substituants sélectionnés indépendamment parmi un alkyle C1-C3, un halo, un amino et un alcoxy C1-C3; les deux R1B ensemble avec l'atome de carbone lesquelles sont attachées se combinent et forment un cycloalkyle C3-C6 ou un hétérocyclyl, où le cycloalkyle est substitué avec C(=O)OR1C, NHC(=O)OR1C ou NHS(=O)2 R1C, et l'hétérocyclyl est substitué avec C(=O)R1C, C(=O)OR1C, S(=O)2 R1C, C(=O)NH2 ou C(=O)NR1CR1C'; q, n, R1C, R2 et R3 sont tels que défini ici, leur utilisation comme des inhibiteurs de RSV et des aspects apparentés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)