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1. (WO2018038575) PHARMACEUTICAL COMPOSITION FOR TREATING RHEUMATOID ARTHRITIS, COMPRISING MESENCHYMAL STEM CELL-DERIVED SECRETORY PROTEOME, AND THERAPEUTIC METHOD USING SAME

Pub. No.:    WO/2018/038575    International Application No.:    PCT/KR2017/009328
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Sat Aug 26 01:59:59 CEST 2017
IPC: A61K 35/28
A61K 9/00
A61K 9/02
A61K 9/08
Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
연세대학교 산학협력단
CATHOLIC KWANDONG UNIVERSITY INDUSTRY FOUNDATION
가톨릭관동대학교산학협력단
Inventors: PARK, Yong Beom
박용범
KIM, Han Soo
김한수
MUN, Chin Hee
문진희
CHOI, Seong Mi
최성미
Title: PHARMACEUTICAL COMPOSITION FOR TREATING RHEUMATOID ARTHRITIS, COMPRISING MESENCHYMAL STEM CELL-DERIVED SECRETORY PROTEOME, AND THERAPEUTIC METHOD USING SAME
Abstract:
The present invention relates to a composition for preventing, ameliorating or treating an autoimmune disease using mesenchymal stem cell-derived secretory proteome. A pharmaceutical composition according to the present invention increases the expression of IL-10, which is a representative immunomodulatory cytokine, and reduces the expression of inflammatory cytokines such as TNF- α, IL-6 and IL-12 (p70), and thus can effectively prevent or treat various autoimmune diseases including rheumatoid arthritis.