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1. (WO2018038539) COMPOSITION FOR ANTI-RNA-VIRUS COMPRISING EPRS PROTEIN OR FRAGMENT THEREOF
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Pub. No.: WO/2018/038539 International Application No.: PCT/KR2017/009224
Publication Date: 01.03.2018 International Filing Date: 23.08.2017
IPC:
C12N 9/00 (2006.01) ,C12N 15/52 (2006.01) ,A61K 38/53 (2006.01) ,A61K 47/64 (2017.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
52
Genes encoding for enzymes or proenzymes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
53
Ligases (6)
[IPC code unknown for A61K 47/64]
Applicants:
한국생명공학연구원 KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 대전시 유성구 과학로 125 125, Gwahak-ro, Yuseong-gu, Daejeon 34141, KR
재단법인 의약바이오컨버젼스연구단 MEDICINAL BIOCONVERGENCE RESEARCH CENTER [KR/KR]; 경기도 수원시 영통구 광교로 145, B동 8층 B dong 8th floor, 145, Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16229, KR
Inventors:
김명희 KIM, Myung Hee; KR
이은영 LEE, Eun Young; KR
김성훈 KIM, Sung Hoon; KR
이철호 LEE, Chul Ho; KR
Agent:
손민 SON, Min; KR
Priority Data:
10-2016-010703723.08.2016KR
Title (EN) COMPOSITION FOR ANTI-RNA-VIRUS COMPRISING EPRS PROTEIN OR FRAGMENT THEREOF
(FR) COMPOSITION POUR UN ANTI-VIRUS À ARN COMPRENANT UNE PROTÉINE EPRS OU UN FRAGMENT DE CELLE-CI
(KO) EPRS 단백질 또는 이의 단편을 포함하는 항RNA-바이러스용 조성물
Abstract:
(EN) The present invention relates to a composition for an anti-RNA virus comprising a glutamyl-prolyl-tRNA synthetase (EPRS) protein or a fragment thereof, a composition for preventing or treating an RNA virus infection disease, and a method for preventing or treating an RNA virus infection disease using the composition. The composition comprising an EPRS protein or a fragment thereof of the present invention has an anti-RNA viral effect by binding to a PCBP2 protein and activating the MAVS signal transduction pathway, and thus has an excellent effect as a composition for preventing or treating RNA infectious diseases.
(FR) La présente invention concerne une composition pour un anti-virus à ARN comprenant une protéine glutamyl-prolyl-ARNt synthétase (EPRS) ou un fragment de celle-ci, une composition pour prévenir ou traiter une maladie infectieuse à virus à ARN, et un procédé pour prévenir ou traiter une maladie infectieuse à virus à ARN à l'aide de la composition. La composition comprenant une protéine EPRS ou un fragment de celle-ci de la présente invention présente un effet anti-virus à ARN par liaison à une protéine PCBP2 et activation de la voie de transduction de signal MAVS, et présente donc un excellent effet en tant que composition pour la prévention ou le traitement de maladies infectieuses à virus à ARN.
(KO) 본 발명은 EPRS (glutamyl-prolyl-tRNA synthetase) 단백질 또는 이의 단편을 포함하는 항RNA 바이러스용 조성물, RNA 바이러스 감염 질환의 예방 또는 치료용 조성물, 및 상기 조성물을 이용한 RNA 바이러스 감염 질환의 예방 또는 치료 방법에 관한 것이다. 본 발명의 EPRS 단백질 또는 이의 단편을 포함하는 조성물은 PCBP2 단백질에 결합하여 MAVS 신호전달 경로를 활성화시킴으로써 항RNA 바이러스 효과를 가지므로, RNA 감염 질환의 예방 또는 치료용 조성물로 우수한 효과가 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)