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1. (WO2018038426) ACID ADDITION SALT OF DIAMINE DERIVATIVE AND PREPARATION METHOD THEREFOR
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Pub. No.: WO/2018/038426 International Application No.: PCT/KR2017/008576
Publication Date: 01.03.2018 International Filing Date: 08.08.2017
IPC:
C07C 271/24 (2006.01) ,C07C 269/06 (2006.01) ,C07C 269/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
24
with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
by reactions not involving the formation of carbamate groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
08
Separation; Purification; Stabilisation; Use of additives
Applicants:
동화약품주식회사 DONG WHA PHARM. CO., LTD. [KR/KR]; 서울시 중구 후암로 98, 19층 19th Floor, 98, Huam-ro Jung-gu Seoul 04637, KR
Inventors:
오윤석 OH, Yoon Seok; KR
신동혁 SHIN, Dong Hyuk; KR
정진용 JUNG, Jin Yong; KR
최동락 CHOI, Dong Rack; KR
Agent:
안소영 AHN, So Young; KR
Priority Data:
10-2016-010705023.08.2016KR
Title (EN) ACID ADDITION SALT OF DIAMINE DERIVATIVE AND PREPARATION METHOD THEREFOR
(FR) SEL D'ADDITION D'ACIDE DE DÉRIVÉ DE DIAMINE ET SON PROCÉDÉ DE PRÉPARATION
(KO) 디아민 유도체의 산부가염 및 이의 제조 방법
Abstract:
(EN) The present invention relates to: a novel acid addition salt of an optically active diamine derivative; and a preparation method therefor. The diamine derivative acid addition salt of the present invention can prepare edoxaban with high purity and in a high yield, and is non-toxic, and a preparation method enabling preparation thereof through a relatively simple process at low cost is provided, thereby being economical in terms of cost and/or time and being advantageous for mass production, so as to be useful in industrialization.
(FR) La présente invention concerne : un nouveau sel d'addition d'acide d'un dérivé de diamine optiquement actif; et son procédé de préparation. Le sel d'addition d'acide dérivé de diamine de la présente invention peut préparer de l'edoxaban avec une pureté élevée et un rendement élevé, et est non toxique. Un procédé de préparation permettant la préparation de celui-ci par un procédé relativement simple à faible coût est fourni, ce qui est économique en termes de coût et/ou de temps et est avantageux pour la production de masse, de manière à être utile dans l'industrialisation.
(KO) 본 발명은 광학 활성 디아민 유도체의 신규한 산부가염 및 이의 제조 방법에 관한 것이다. 본 발명의 디아민 유도체의 산부가염은 에독사반을 고순도 및 고수율로 제조할 수 있고, 독성 문제가 없으며, 비교적 간단한 공정 및 저렴한 비용으로 제조할 수 있는 제조 방법을 제공하여, 비용 및/또는 시간 면에서 경제적으로, 대량 생산에 유리하여 산업화에 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)