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1. (WO2018038352) AUTOANTIBODY BIOMARKER FOR DIAGNOSING DEMENTIA AND METHOD FOR DIAGNOSING DEMENTIA BY USING SAME
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Pub. No.: WO/2018/038352 International Application No.: PCT/KR2017/004836
Publication Date: 01.03.2018 International Filing Date: 10.05.2017
IPC:
G01N 33/68 (2006.01) ,G01N 33/543 (2006.01) ,G01N 33/558 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
558
using diffusion or migration of antigen or antibody
Applicants:
대한민국(관리부서 질병관리본부장) KOREA CENTER FOR DISEASE CONTROL AND PREVENTION [KR/KR]; 충청북도 청주시 흥덕구 오송읍 오송생명2로 187 187, Osongsaengmyeong 2-ro Osong-eup, Heungdeok-gu, Cheongju-si Chungcheongbuk-do 28159, KR
Inventors:
전재필 JEON, Jae-Pil; KR
심성미 SHIM, Sung-Mi; KR
송지현 SONG, Jihyun; KR
Agent:
이원희 LEE, Won Hee; KR
Priority Data:
10-2016-010596922.08.2016KR
Title (EN) AUTOANTIBODY BIOMARKER FOR DIAGNOSING DEMENTIA AND METHOD FOR DIAGNOSING DEMENTIA BY USING SAME
(FR) BIOMARQUEUR D'AUTO-ANTICORPS PERMETTANT DE DIAGNOSTIQUER LA DÉMENCE ET MÉTHODE DE DIAGNOSTIC DE LA DÉMENCE UTILISANT CELUI-CI
(KO) 치매진단용 자가항체 바이오마커 및 이를 이용한 치매진단 방법
Abstract:
(EN) The present invention relates to an autoantibody biomarker for diagnosing dementia and a kit for diagnosing dementia comprising the same. In particular, the present invention relates to an autoantibody biomarker that selectively recognizes Ataxia, Cerebellar, Cayman Type (ATCAY), NME/NM23 Family Member 7 (NME7) and Nucleolar Protein 3 (NOL3) which can be used for the diagnosis of dementia as the amounts thereof are specifically increased in the blood of a dementia patient compared to a normal person, and a diagnostic kit for diagnosing dementia comprising an antigen recognizing the same. The dementia diagnostic kit including the autoantibodies of ATCAY, NME7 and NOL3 which can be used as a marker for diagnosing dementia of the present invention can diagnose dementia very easily by using the blood of a patient, and thus can effectively be used for early diagnosis of dementia.
(FR) La présente invention concerne un biomarqueur d'auto-anticorps permettant de diagnostiquer la démence et un kit permettant de diagnostiquer la démence comprenant celui-ci. En particulier, la présente invention concerne un biomarqueur d'auto-anticorps qui reconnaît sélectivement l'ataxie cérébelleuse de type Caïman (ATCAY), l'élément 7 de la famille NME/NM23 (NME7) et la protéine nucléolaire 3 (NOL3) qui peuvent être utilisés pour le diagnostic de la démence étant donné que leurs quantités sont spécifiquement accrues dans le sang d'un patient souffrant de démence par comparaison avec une personne normale, et un kit de diagnostic permettant de diagnostiquer la démence comprenant un antigène reconnaissant celle-ci. Le kit de diagnostic de la démence de la présente invention, comprenant les auto-anticorps d'ATCAY, NME7 et NOL3 qui peuvent être utilisés en tant que marqueur pour diagnostiquer la démence, peut diagnostiquer la démence très facilement à l'aide du sang d'un patient, et peut ainsi être utilisé efficacement pour un diagnostic précoce de la démence.
(KO) 본 발명은 치매 진단용 자가항체 바이오마커 및 이를 포함하는 치매 진단용 키트에 관한 것으로, 구체적으로 정상인에 비하여 치매 환자의 혈액 내에서 그 양이 특이적으로 증가하여 치매를 진단할 수 있는 ATCAY(Ataxia, Cerebellar, Cayman Type), NME7(NME/NM23 Family Member 7) 및 NOL3(Nucleolar Protein 3)를 각각 선택적으로 인식하는 자가항체 바이오마커, 이를 인식하는 항원을 포함한 치매 진단용 진단 키트에 관한 것이다. 본 발명의 치매 진단용 마커로 사용할 수 있는 ATCAY, NME7 및 NOL3의 자가항체를 포함하는 치매 진단 키트는 환자의 혈액을 이용하여 매우 간편하게 치매를 진단할 수 있어 치매의 조기 진단에 유용하게 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)