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1. (WO2018038248) MODIFIED LUCIFERASE

Pub. No.:    WO/2018/038248    International Application No.:    PCT/JP2017/030491
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Sat Aug 26 01:59:59 CEST 2017
IPC: C12N 9/02
C12N 15/09
C12Q 1/66
Applicants: RIKEN
国立研究開発法人理化学研究所
Inventors: MIYAWAKI, Atsushi
宮脇 敦史
IWANO, Satoshi
岩野 智
Title: MODIFIED LUCIFERASE
Abstract:
The purpose of the present invention is to provide modified luciferase having improved substrate specificity to at least one luminescent substrate (e.g., Akalumine) other than D-luciferin compared with substrate specificity to D-luciferin. Modified luciferase according to one aspect of the present invention has a mutation of an amino acid residue corresponding to the amino acid residue located at position-347 in the amino acid sequence represented by SEQ ID NO: 1.