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1. (WO2018037416) METHODS AND COMPOSITIONS FOR TREATING AUTOIMMUNE DISEASES

Pub. No.:    WO/2018/037416    International Application No.:    PCT/IL2017/050945
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Fri Aug 25 01:59:59 CEST 2017
IPC: A61K 38/16
A61K 39/12
A61P 37/06
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventors: SHAI, Yechiel
ROTEM, Etai
KLUG, Yoel
SCHWARZER, Roland
FAINGOLD, Omri
Title: METHODS AND COMPOSITIONS FOR TREATING AUTOIMMUNE DISEASES
Abstract:
Provided are methods of inhibiting proliferation of a T cell by contacting the T cell with a peptide comprising an amino acid sequence which comprises a consensus sequence motif selected from the group consisting of SEQ ID NOs: 12-17 and 85, wherein said amino acid sequence is capable of inhibiting T cell proliferation. Also provided are methods and pharmaceutical compositions for treating a T cell mediated autoimmune disease. Also provided is a peptide comprising an amino acid sequence which comprises a consensus sequence motif selected from the group consisting of SEQ ID NOs: 12-17 and 85, wherein the peptide is capable of inhibiting T cell proliferation.