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1. (WO2018037407) METHOD AND SYSTEM FOR SUBCUTANEOUS SENSING

Pub. No.:    WO/2018/037407    International Application No.:    PCT/IL2017/050935
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Wed Aug 23 01:59:59 CEST 2017
IPC: A61B 5/145
A61B 5/1473
A61B 5/1486
A61B 5/1495
A61M 37/00
G01N 27/414
Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventors: PATOLSKY, Fernando
KRIVITSKY, Vadim
HEIFLER, Omri
ZVERZHINETSKY, Marina
Title: METHOD AND SYSTEM FOR SUBCUTANEOUS SENSING
Abstract:
A system for monitoring at least presence of a bioanalyte. The system comprises: a substrate having a skin contact surface, a microneedle outwardly protruding from the skin contact surface, a sensing complex positioned in the microneedle, and a circuit attached to the substrate. The sensing complex can comprise a nanostructure modified by a functional moiety covalently attached thereto, and an affinity moiety effective to react specifically with the bioanalyte to produce a reaction product. The circuit can apply voltage to the nanostructure and monitor changes in an electrical property of the nanostructure responsively to reaction between the reaction product and the functional moiety.