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1. (WO2018037402) BIOREACTOR AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/037402    International Application No.:    PCT/IL2017/050927
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Tue Aug 22 01:59:59 CEST 2017
IPC: B01D 61/14
C12M 3/02
C12M 3/06
Applicants: ADVA BIOTECHNOLOGY LTD.
Inventors: KARNIELI, Ohad
Title: BIOREACTOR AND METHODS OF USE THEREOF
Abstract:
An inverted conical bioreactor is provided for growing cells or microorganisms. The bioreactor has an internal space and a perforated barrier within the vessel, through which a liquid may flow, where cells or microorganisms cannot pass through the perforated barrier. The perforated barrier divides the internal space of the bioreactor into a first chamber and a second chamber. Cells are grown within the second chamber and can be perfused by re-circulating the liquid, for example a growth medium, through the bioreactor. Various inlet ports and outlet ports allow controlling the parameters of flow of the growth medium.