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1. (WO2018037134) CELL SUSPENSION FOR USE IN THE TREATMENT OF LOWER EXTREMITY PERIPHERAL ARTERY DISEASE
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Pub. No.: WO/2018/037134 International Application No.: PCT/EP2017/071580
Publication Date: 01.03.2018 International Filing Date: 28.08.2017
Chapter 2 Demand Filed: 28.11.2017
IPC:
C12N 5/078 (2010.01) ,C12N 5/0789 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0789
Stem cells; Multipotent progenitor cells
Applicants:
REXGENERO BIOSCIENCES, S.L. [ES/ES]; Calle Max Planck 3 (Ed. Iris II, Isla de la Cartuja) 41092 Sevilla, ES
SERVICIO ANDALUZ DE SALUD [ES/ES]; Avda. de la Constitucion, 18 41071 Sevilla, ES
FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD [ES/ES]; Avda. Américo Vespucio, 15, Edificio S2. Parque Científico y Tecnológico Cartuja 41092 Sevilla, ES
Inventors:
DUPERE, Jonathan Robert Barclay; ES
DE JONG, LIesbeth; ES
WAGENA, Edwin J; ES
Agent:
HOFFMANN EITLE, S.L.U.; Paseo de la Castellana 140 Planta 3ª, Edificio Lima 28046 Madrid, ES
Priority Data:
16382405.526.08.2016EP
Title (EN) CELL SUSPENSION FOR USE IN THE TREATMENT OF LOWER EXTREMITY PERIPHERAL ARTERY DISEASE
(FR) SUSPENSION CELLULAIRE DESTINÉE À ÊTRE UTILISÉE DANS LE TRAITEMENT D'UNE MALADIE ARTÉRIELLE PÉRIPHÉRIQUE DES EXTRÉMITÉS INFÉRIEURES
Abstract:
(EN) The present invention refers to a cell suspension of autologous or allogeneic, preferably autologous, adult bone marrow-derived white blood cells, preferably derived from the crest of the ilium (or iliac crest), enriched for mononuclear cells, meaning more than 25% of the white blood cells (WBCs) present in the cell suspension are mononuclear cells, and comprising: A.Mononuclear cells (MNC) selected from the list comprising or consisting of: i. A population of Lymphocytes; ii. A population of Monocytes; and iii. A population of Hematopoietic stem cells expressing CD34; and wherein the cell suspension further comprises: B.Granulocytes; for use in the treatment or amelioration of lower extremity peripheral artery disease.
(FR) La présente invention concerne une suspension cellulaire de globules blancs autologues ou allogènes, de préférence autologues, dérivés de la moelle osseuse adulte, de préférence dérivés de la crête de l'ilium (ou de la crête iliaque), enrichie en cellules mononucléaires, ce qui signifie que plus de 25 % des globules blancs (GB) présents dans la suspension cellulaire sont des cellules mononucléaires, et comprenant : A. des cellules mononucléaires (CMN) choisies dans la liste comprenant ou consistant en : i. une population de lymphocytes ; ii. une population de monocytes ; et iii. une population de cellules souches hématopoïétiques exprimant CD34 ; et la suspension cellulaire comprenant en outre : B. des granulocytes ; destinée à être utilisée dans le traitement ou l'amélioration d'une maladie artérielle périphérique des extrémités inférieures.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)