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1. (WO2018037119) PRODRUGS ACTIVATED BY REACTIVE OXYGEN SPECIES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES AND CANCER

Pub. No.:    WO/2018/037119    International Application No.:    PCT/EP2017/071456
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Sat Aug 26 01:59:59 CEST 2017
IPC: C07D 487/04
A61K 31/519
A61P 29/00
A61P 35/00
Applicants: DANMARKS TEKNISKE UNIVERSITET
Inventors: PEIRÓ CADAHÍA, Jorge
CLAUSEN, Mads, Hartvig
BONDEBJERG, Jon
HANSEN, Christian, Abildgaard
ANDERSEN, Nikolaj, Sten
Title: PRODRUGS ACTIVATED BY REACTIVE OXYGEN SPECIES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES AND CANCER
Abstract:
Prodrugs activated predominantly or exclusively in inflammatory tissue, more particularly prodrugs of methotrexate and derivatives thereof, which are selectively activated by Reactive Oxygen Species (ROS) in inflammatory tissues associated with cancer and inflammatory diseases, as well as method for preparing said prodrugs.