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1. (WO2018037092) MULTISPECIFIC ANTIBODIES FACILITATING SELECTIVE LIGHT CHAIN PAIRING
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/037092 International Application No.: PCT/EP2017/071375
Publication Date: 01.03.2018 International Filing Date: 24.08.2017
IPC:
C07K 16/00 (2006.01) ,C07K 16/24 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
Applicants: SANOFI[FR/FR]; 54 rue la Boétie 75008 Paris, FR
Inventors: RAO, Ercole; DE
BEIL, Christian; DE
LANGE, Christian; DE
KROLL, Katja; DE
LEUSCHNER, Wulf-Dirk; DE
FOCKEN, Ingo; DE
LANGER, Thomas; DE
SPINDLER, Nadja; DE
Agent: ZWICKER, Jörk; ZSP Patentanwälte Partg mbB Hansastr. 32 80686 München, DE
Priority Data:
16306087.426.08.2016EP
Title (EN) MULTISPECIFIC ANTIBODIES FACILITATING SELECTIVE LIGHT CHAIN PAIRING
(FR) ANTICORPS MULTISPÉCIFIQUES FACILITANT L'APPARIEMENT SÉLECTIF DE CHAÎNES LÉGÈRES
Abstract:
(EN) Generally, the present invention relates to the field of antibodies. In particular, it relates to multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. The invention further relates to nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies. The invention also relates to methods of isolating the antibodies.
(FR) De manière générale la présente invention concerne le domaine des anticorps. En particulier, l'invention concerne des anticorps multispécifiques, par exemple des anticorps bispécifiques, qui sont modifiés de telle sorte que l'appariement de chaîne souhaité a lieu et/ou peut être sélectionné. Spécifiquement, ceci est obtenu en utilisant différents domaines de dimérisation pour l'appariement de chaînes légères. L'invention concerne en outre des acides nucléiques codant pour ces anticorps, des vecteurs d'expression comprenant ces acides nucléiques, des cellules les exprimant, et en outre des compositions pharmaceutiques comprenant les anticorps. L'invention concerne également des procédés d'isolement d'anticorps.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)