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1. (WO2018036982) CHEMICAL-BIOCATALYTIC METHOD FOR PRODUCING URSODEOXYCHOLIC ACID
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Pub. No.: WO/2018/036982 International Application No.: PCT/EP2017/071070
Publication Date: 01.03.2018 International Filing Date: 22.08.2017
IPC:
C12P 33/00 (2006.01) ,C12P 33/06 (2006.01) ,C12N 9/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
33
Preparation of steroids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
33
Preparation of steroids
06
Hydroxylating
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
04
acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
Applicants:
PHARMAZELL GMBH [DE/DE]; Rosenheimer Str. 43 83064 Raubling, DE
Inventors:
BAKONYI, Daniel; DE
HUMMEL, Werner; DE
GROSS, Ralf; DE
Agent:
REITSTÖTTER KINZEBACH; Sternwartstraße 4 81679 München, DE
Priority Data:
16185074.822.08.2016EP
Title (EN) CHEMICAL-BIOCATALYTIC METHOD FOR PRODUCING URSODEOXYCHOLIC ACID
(FR) PROCÉDÉ CHIMICO-BIOCATALYTIQUE DE FABRICATION D’ACIDE URSODÉSOXYCHOLIQUE
(DE) CHEMISCH-BIOKATALYTISCHES VERFAHREN ZUR HERSTELLUNG VON URSODESOXYCHOLSÄURE
Abstract:
(EN) The invention relates to a further chemical-biocatalytic method for producing ursodeoxycholic acid from chenodeoxycholic acid after chemical oxidation to 3,7-diketo-ursodeoxycholic acid and after subsequent reaction with 7 beta-hydroxysteroid dehydrogenase from C. aerofaciens and 3 alpha-hydroxysteroid dehydrogenase from C. testosteroni.
(FR) L’invention concerne un autre procédé chimico-biocatalytique de fabrication d’acide ursodésoxycholique, selon lequel de l’acide chénodésoxycholique soumis à une oxydation chimique permet d’obtenir de l’acide 3,7-dikéto-ursodésoxycholique qui, ensuite, est mis à réagir avec 7-béta-hydroxystéroïde-déshydrogénase à partir de C. aerofaciens et 3-alpha- hydroxystéroïd-désydrogénase à partir de C. testosteroni.
(DE) Die Erfindung betrifft ein weiteres chemisch-biokatalytisches Verfahren zur Herstellung von Ursodesoxycholsaure ausgehend von Chenodesoxycholsäure nach chemischer Oxidation zu 3,7-Diketo- Ursodesoxycholsäure und anschließender Umsetzung mit 7-beta- Hydroxysteroid-Dehydrogenase aus C. aerofaciens und 3-alpha- Hydroxysteroid-Dehydrogenase aus C. testosteroni.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)