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1. (WO2018036941) COMBINATION THERAPY OF AN HBV CAPSID ASSEMBLY INHIBITOR AND A NUCLEOS(T)IDE ANALOGUE

Pub. No.:    WO/2018/036941    International Application No.:    PCT/EP2017/070984
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Tue Aug 22 01:59:59 CEST 2017
IPC: A61K 31/506
A61K 31/522
A61K 31/5377
A61K 31/675
A61K 31/7068
A61K 31/7072
A61K 45/06
A61P 31/20
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: NAJERA, Isabel
WILDUM, Steffen
Title: COMBINATION THERAPY OF AN HBV CAPSID ASSEMBLY INHIBITOR AND A NUCLEOS(T)IDE ANALOGUE
Abstract:
The present invention is directed to compositions and uses thereof for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBV capsid assembly inhibitor and a nucleoside or nucleotide analogue for use in the treatment or prophylaxis of chronic hepatitis B patient.