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1. (WO2018036910) CELL CULTURE

Pub. No.:    WO/2018/036910    International Application No.:    PCT/EP2017/070881
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Fri Aug 18 01:59:59 CEST 2017
IPC: C12N 5/071
Applicants: PHILIP MORRIS PRODUCTS S.A.
Inventors: BOVARD, David
LUETTICH, Karsta
Title: CELL CULTURE
Abstract:
There is described an isolated 3-dimensional liver spheroid wherein said spheroid has: increased ATP content as compared to a 3-dimensional liver spheroid cultured in Complete William's E medium alone; the same or increased activity of cytochrome P450 1A1 and cytochrome P450 1B1 as compared to a 3-dimensional liver spheroid cultured in Complete William's E medium alone; and increased albumin secretion as compared to a 3-dimensional liver spheroid cultured in William's E medium alone.