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1. (WO2018036785) PEPTIDES HAVING TrkA-RECEPTOR-AGONISTIC ACTIVITY AND/OR PEPTIDES HAVING NGF-ANTAGONISTIC ACTIVITY

Pub. No.:    WO/2018/036785    International Application No.:    PCT/EP2017/069705
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Fri Aug 04 01:59:59 CEST 2017
IPC: C07K 7/08
A61K 38/10
Applicants: NEUHEART S.R.L.
Inventors: FANTUCCI, Piercarlo
GOVONI, Stefano
PASCALE, Alessia Angela
MARCHESI, Nicoletta
VANOLI, Emilio
VERTEMARA, Jacopo
VITRIOLO, Alessandro Concetto
Title: PEPTIDES HAVING TrkA-RECEPTOR-AGONISTIC ACTIVITY AND/OR PEPTIDES HAVING NGF-ANTAGONISTIC ACTIVITY
Abstract:
The present invention relates to novel peptides and peptide fragments and the uses thereof. In particular, the present invention relates to peptides or peptide fragments having TrkA- receptor-agonistic activity useful in the treatment, prevention or control of diseases and disorders such as peripheral neuropathies, multiple sclerosis, Alzheimer's disease, Parkinson's disease, hypoxic cerebral lesions, ischaemic heart disease, heart failure and diabetes and the comorbidities thereof, in particular diabetic neuropathies, optic nerve atrophy, ulcers, keratitis and/or glaucoma. The invention further discloses peptides and peptide fragments having NGF-antagonistic activity useful in the treatment, prevention or control of diseases and disorders such as pain, hyperinnervation, cardiac arrhythmias and sudden cardiac death.