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1. (WO2018036414) FUSED HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/036414 International Application No.: PCT/CN2017/097660
Publication Date: 01.03.2018 International Filing Date: 16.08.2017
IPC:
C07D 471/04 (2006.01) ,C07D 231/56 (2006.01) ,A61K 31/4164 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54
condensed with carbocyclic rings or ring systems
56
Benzopyrazoles; Hydrogenated benzopyrazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
北京诺诚健华医药科技有限公司 BEIJING INNOCARE PHARMA TECH CO., LTD. [CN/CN]; 中国北京市 昌平区科技园区生命园路8号院一区8号楼 Bldg.8, Community No. 1, No.8 Courtyard Life Park Road, ZGC Life Science Park, Changping District Beijing 102206, CN
Inventors:
陈向阳 CHEN, Xiangyang; CN
高英祥 GAO, Yingxiang; CN
Agent:
中国专利代理(香港)有限公司 CHINA PATENT AGENT (H.K.) LTD.; 中国香港特别行政区 湾仔港湾道23号鹰君中心22号楼 22/F, Great Eagle Centre 23 Harbour Road, Wanchai Hong Kong, CN
Priority Data:
201610705318.923.08.2016CN
Title (EN) FUSED HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
(FR) DÉRIVÉ HÉTÉROCYCLIQUE FUSIONNÉ, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION MÉDICALE
(ZH) 稠杂环类衍生物、其制备方法及其在医学上的应用
Abstract:
(EN) Disclosed are a new derivative as shown by general formula (I') or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the derivative or the pharmaceutically acceptable salt thereof, and a method for preparing the derivative or the pharmaceutically acceptable salt. Disclosed is the use of the derivative or the pharmaceutically acceptable salt thereof or the pharmaceutical composition containing the derivative or the pharmaceutically acceptable salt thereof in the preparation of a medicine, in particular an IDO inhibitor medicine and a medicine for treating and/or preventing a tumour. Each substituent of the general formula (I') is the same as defined in the description.
(FR) L'invention concerne un nouveau dérivé tel que représenté par la formule générale (I') ou un sel pharmaceutiquement acceptable de celui-ci, une composition pharmaceutique contenant le dérivé ou son sel pharmaceutiquement acceptable, et un procédé de préparation du dérivé ou du sel pharmaceutiquement acceptable. L'invention concerne l'utilisation du dérivé ou du sel pharmaceutiquement acceptable de celui-ci ou de la composition pharmaceutique contenant le dérivé ou son sel pharmaceutiquement acceptable dans la préparation d'un médicament, en particulier un médicament inhibiteur d'IDO et un médicament pour traiter et/ou prévenir une tumeur. Chaque substituant de formule générale (I') est le même que défini dans la description.
(ZH) 一种通式(I')所示的新的衍生物或其可药用的盐、含有所述衍生物或其可药用的盐的药物组合物及所述衍生物或其可药用的盐的制备方法。所述衍生物或其可药用的盐或含有所述衍生物或其可药用的盐的药物组合物在制备药物,特别是IDO抑制剂药物和治疗和/或预防肿瘤的药物中的用途。其中通式(I')的各取代基同说明书中的定义相同。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)