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1. (WO2018036403) OLIGOSACCHARIDE LINKER AND ANTIBODY-DRUG CONJUGATE WITH SITE-SPECIFIC LINKAGE PREPARED USING THE OLIGOSACCHARIDE LINKER

Pub. No.:    WO/2018/036403    International Application No.:    PCT/CN2017/097439
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Wed Aug 16 01:59:59 CEST 2017
IPC: C08B 37/00
C12P 19/04
C12P 19/14
C07K 17/10
A61K 39/44
A61P 35/00
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
中国科学院上海药物研究所
Inventors: HUANG, Wei
黄蔚
GENG, Meiyu
耿美玉
HUANG, Min
黄敏
TANG, Feng
唐峰
TANG, Yubo
唐宇博
YANG, Yang
杨洋
TANG, Shuai
唐帅
Title: OLIGOSACCHARIDE LINKER AND ANTIBODY-DRUG CONJUGATE WITH SITE-SPECIFIC LINKAGE PREPARED USING THE OLIGOSACCHARIDE LINKER
Abstract:
A novel oligosaccharide linker. The oligosaccharide linker is used to prepare an antibody-drug conjugate with site-specific linkage and an antibody-drug conjugate with two coupled drugs. The oligosaccharide linker comprises a biantennary N-linked glycan, a terminal sialic acid provided with a modification group Y-(CH2)n-X, and a terminal acetylglucosamine comprising an oxazoline. The antibody-drug conjugate and the antibody-drug conjugate with two coupled drugs can be used to prepare a pharmaceutical product for anti-tumor, anti-inflammation, anti-virus, anti-infection, or other forms of immunotherapy.