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1. (WO2018035616) COMPOSITIONS AND METHODS FOR THE TREATMENT OF CAST NEPHROPATHY AND RELATED CONDITIONS
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Pub. No.: WO/2018/035616 International Application No.: PCT/CA2017/051003
Publication Date: 01.03.2018 International Filing Date: 25.08.2017
IPC:
C07K 7/08 (2006.01) ,A61K 38/10 (2006.01) ,A61P 25/00 (2006.01) ,C07K 14/705 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10
Peptides having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
Applicants:
LEGER, Roger [CA/CA]; CA
DUBE, Gilles [CA/CA]; CA
CARUSO, Marie-Elaine [CA/CA]; CA
ROSSERT, Jerome [US/US]; US
THRASOS THERAPEUTICS INC. [CA/CA]; 7171 Frederick-Banting Montreal, Québec H4S 1Z9, CA
Inventors:
LEGER, Roger; CA
DUBE, Gilles; CA
CARUSO, Marie-Elaine; CA
ROSSERT, Jerome; US
Agent:
VICKERS, Mark F.; CA
DAMIANI, Michael; CA
EVENSON, Brandon; CA
FRITZ, Joachim T.; CA
WOOD, David; CA
ALLARD, Louis B.; CA
BEHMANN, Curtis B.; CA
BOOCOCK, Graeme R.; CA
DEKLEINE, Geoffrey; CA
HUNG, Shin; CA
KEELER, Todd; CA
MARSMAN, Kathleen E.; CA
MUELLER-NEUHAUS, Jason R.; CA
NAUMAN, David A.; CA
PUNDSACK, Scott; CA
COGHLAN, Jeffrey; CA
GORDON, Jeff; CA
RAOUL, Jennifer; CA
SILVER, Gail C.; CA
SOJONKY, Andrew D.; CA
WEBB, Timothy; CA
ZIMMERMAN, Gord; CA
Priority Data:
62/380,06826.08.2016US
Title (EN) COMPOSITIONS AND METHODS FOR THE TREATMENT OF CAST NEPHROPATHY AND RELATED CONDITIONS
(FR) COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE NÉPHROPATHIE ET DES ÉTATS PATHOLOGIQUES ASSOCIÉS
Abstract:
(EN) Provided are novel peptides of Formula SEQ ID No. 1: J1CysX1X2X3X4X5X6ProX7ThrCysJ2J3(J4)s(J5)t; (SEQ ID No. 1) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are which are effective inhibitors of light chains to uromodulin.
(FR) L'invention concerne de nouveaux peptides de formule SEQ ID No. 1: J1CysX1X2X3X4X5X6ProX7ThrCysJ2J3(J4)s(J5)t; (SEQ ID No. 1) Sels pharmaceutiquement acceptables de ceux-ci, et des compositions pharmaceutiques de ceux-ci, qui sont des inhibiteurs effectives des chaines légères d'uromoduline.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)