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1. (WO2018035615) COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES
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Pub. No.: WO/2018/035615 International Application No.: PCT/CA2017/051001
Publication Date: 01.03.2018 International Filing Date: 25.08.2017
IPC:
C07K 7/08 (2006.01) ,A61K 38/10 (2006.01) ,A61P 1/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10
Peptides having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
Applicants:
THRASOS THERAPEUTICS INC. [CA/CA]; 7171 Frederick-Banting Montreal, Québec H4S 1Z9, CA
Inventors:
LEGER, Roger; CA
ROSSERT, Jerome; US
CARUSO, Marie-Elaine; CA
Agent:
VICKERS, Mark F.; CA
DAMIANI, Michael; CA
EVENSON, Brandon; CA
FRITZ, Joachim T.; CA
ALLARD, Louis B.; CA
BEHMANN, Curtis B.; CA
BOOCOCK, Graeme R.; CA
DEKLEINE, Geoffrey; CA
HUNG, Shin; CA
KEELER, Todd; CA
MARSMAN, Kathleen E.; CA
MUELLER-NEUHAUS, Jason R.; CA
NAUMAN, David A.; CA
PUNDSACK, Scott; CA
COGHLAN, Jeffrey; CA
GORDON, Jeff; CA
RAOUL, Jennifer; CA
SILVER, Gail C.; CA
SOJONKY, Andrew D.; CA
WEBB, Timothy; CA
WOOD, David; CA
ZIMMERMAN, Gord; CA
Priority Data:
62/380,07526.08.2016US
Title (EN) COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES
(FR) COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT D'UNE MALADIE INFLAMMATOIRE DE L'INTESTIN
Abstract:
(EN) Provided are novel peptides of Formula SEQ ID No. 1: J1CysX1X2X3X4X5X6,ProX7ThrCysJ2J3(J4)5(J5)1; (SEQ ID No. 1 ) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are which are effective inhibitors of light chains to uromodulin.
(FR) L'invention concerne de nouveaux peptides de formule (SEQ ID No. 1 : J1CysX1X2X3X4X5X6,ProX7ThrCysJ2J3(J4)5(J5)1; (SEQ ID No. 1) L'invention concerne également des sels pharmaceutiquement acceptables de ceux-ci, et des compositions pharmaceutiques de ceux-ci, qui sont des inhibiteurs efficaces de chaînes légères à l'uromoduline.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)