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1. (WO2018035569) DIAGNOSTIC METHODS AND DEVICE

Pub. No.:    WO/2018/035569    International Application No.:    PCT/AU2017/050900
Publication Date: Fri Mar 02 00:59:59 CET 2018 International Filing Date: Fri Aug 25 01:59:59 CEST 2017
IPC: G01N 11/02
G01N 29/02
Applicants: RMIT UNIVERSITY
THE UNIVERSITY OF MELBOURNE
Inventors: DOWNIE, Laura, Elizabeth
YEO, Leslie
MCDONNELL, Amarin, George
Title: DIAGNOSTIC METHODS AND DEVICE
Abstract:
A method for evaluating Dry Eye Disease (DED) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry (ADMiER) instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry (ADMiER) instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.