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1. (WO2018035563) SYSTEMIC INFLAMMATORY AND PATHOGEN BIOMARKERS AND USES THEREFOR
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Pub. No.: WO/2018/035563 International Application No.: PCT/AU2017/050894
Publication Date: 01.03.2018 International Filing Date: 24.08.2017
IPC:
C12Q 1/68 (2006.01) ,G01N 33/569 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
IMMUNEXPRESS PTY LTD [AU/AU]; 6 Leonard Street Boonah, Queensland 4310, AU
Inventors:
BRANDON, Richard Bruce; AU
SAMPSON, Dayle Lorand; US
MCHUGH, Leo Charles; US
Agent:
DAVIES COLLISON CAVE PTY LTD; 10/301 Coronation Drive Milton, Queensland 4064, AU
Priority Data:
201690337024.08.2016AU
Title (EN) SYSTEMIC INFLAMMATORY AND PATHOGEN BIOMARKERS AND USES THEREFOR
(FR) BIOMARQUEURS SYSTÉMIQUES INFLAMMATOIRES ET PATHOGÈNES ET LEURS UTILISATIONS
Abstract:
(EN) Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring an infection by a bacterium, virus or protozoan by measurement of pathogen- associated and non-infectious systemic inflammation and optionally in combination with detection of a pathogen specific molecule. The invention can be used for diagnosis, including early diagnosis, ruling-out, ruling-in, monitoring, making treatment decisions, or management of subjects suspected of, or having, systemic inflammation. More particularly, the present disclosure relates to host peripheral blood RNA and protein biomarkers, which are used in combination, and optionally with peripheral blood broad-range pathogen-specific detection assays, that are useful for distinguishing between bacterial, viral, protozoal and non-infectious causes of systemic inflammation.
(FR) L'invention concerne des compositions, des procédés et un appareil de diagnostic et/ou de surveillance d'une infection par une bactérie, un virus ou un protozoaire par mesure d'une inflammation systémique associée à un pathogène et non infectieuse et éventuellement en combinaison avec la détection d'une molécule spécifique d'un agent pathogène. L'invention peut être utilisée pour établir un diagnostic, y compris un diagnostic précoce, pour écarter, statuer, surveiller, prendre des décisions thérapeutiques, ou prendre en charge des sujets suspectés de souffrir, ou souffrant, d'une inflammation systémique. Plus particulièrement, la présente invention concerne des biomarqueurs d'ARN et de protéine du sang périphérique hôte, qui sont utilisés en combinaison, et éventuellement avec des dosages de détection spécifiques des pathogènes à large spectre dans le sang périphérique, qui sont utiles pour différencier des causes bactériennes, virales, protozoaires et non infectieuses d'une inflammation systémique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)