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1. (WO2018035509) SMALL MOLECULES HAVING ANTIVIRAL PROPERTIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/035509    International Application No.:    PCT/US2017/047699
Publication Date: 22.02.2018 International Filing Date: 19.08.2017
IPC:
A61K 31/53 (2006.01), C07D 487/04 (2006.01)
Applicants: GRL, INC. [US/US]; 401 Professional Drive Suite 130 Gaithersburg, MD 20879 (US).
KISELEV, Oleg, I. [RU/RU]; (RU).
RUSINOV, Vladimir [RU/RU]; (RU).
ULOMSKY, Evgeny [RU/RU]; (RU).
MEDVEDEVA, Natalia [RU/RU]; (RU).
SAPOZHNIKOVA, Irina [RU/RU]; (RU).
CHARUSHIN, Valery [RU/RU]; (RU).
CHUPAKHIN, Oleg [RU/RU]; (RU).
DANILENKO, Daria [RU/RU]; (RU).
DEEVA, Ella [RU/RU]; (RU)
Inventors: KISELEV, Oleg, I.; (RU).
RUSINOV, Vladimir; (RU).
ULOMSKY, Evgeny; (RU).
MEDVEDEVA, Natalia; (RU).
SAPOZHNIKOVA, Irina; (RU).
CHARUSHIN, Valery; (RU).
CHUPAKHIN, Oleg; (RU).
DANILENKO, Daria; (RU).
DEEVA, Ella; (RU)
Agent: HOYTE, Alfred, F., Jr.; (US)
Priority Data:
62/377,413 19.08.2016 US
Title (EN) SMALL MOLECULES HAVING ANTIVIRAL PROPERTIES
(FR) PETITES MOLÉCULES AYANT DES PROPRIÉTÉS ANTIVIRALES
Abstract: front page image
(EN)The present invention relates to salt forms and derivatives of 2-methylthio-6-nitro-1,2,4-triazoio[5, 1-c]1,2,4-triazine-7-one, dehydrate and pharmaceutical compositions thereof. These salt forms and derivatives exhibit improved antiviral activity. The present invention also relates to processes for preparing the compounds, and intermediates used in their preparation.
(FR)La présente invention concerne des formes de sel et des dérivés de 2-méthylthio-6-nitro-1,2,4-triazolo[5,1-c]1,2,4-triazine-7-one dihydratée, et des compositions pharmaceutiques de ceux-ci. Ces formes de sel et dérivés présentent une activité antivirale améliorée. La présente invention concerne en outre des procédés de préparation des composés, et des intermédiaires utilisés dans leur préparation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)